Sustained scleral stiffening in rats after a single genipin treatment
نویسندگان
چکیده
منابع مشابه
Quantification of the efficacy of collagen cross-linking agents to induce stiffening of rat sclera.
The concept of scleral stiffening therapies has emerged as a novel theoretical approach for treating the ocular disorders glaucoma and myopia. Deformation of specific regions of the posterior eye is innately involved in the pathophysiology of these diseases, and thus targeted scleral stiffening could resist these changes and slow or prevent progression of these diseases. Here, we present the fi...
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Alpha-1antitrypsin (A1AT) deficiency, an inherited disorder, has been shown to be the cause of lung diseases such as emphysema and chronic obstructive pulmonary disease. One of the treatment strategies to provide appropriate and adequate concentrations of A1AT in the lungsis the application of nanoparticles (NPs) in pulmonary drug delivery. In the current study, biocompatible nanohydrogels were...
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PURPOSE Scleral stiffening has been proposed as a treatment for glaucoma to protect the lamina cribrosa (LC) from excessive intraocular pressure-induced deformation. Here we experimentally evaluated the effects of moderate stiffening of the peripapillary sclera on the deformation of the LC. METHODS An annular sponge, saturated with 1.25% glutaraldehyde, was applied to the external surface of ...
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purpose: to compare the safety, efficacy, and visual results of laser in situ keratomileusis (lasik) in eyes with and without previous scleral buckling surgery in the same individuals. methods: in a prospective clinical trial, 14 eyes of 7 patients with myopic refractive error and history of scleral buckling in one eye, underwent lasik surgery in both eyes according to a standard surgical proto...
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Mitomycin (MMC) has been associated with a variety of complications, including corneoscleral melt. We report the successful repair of a scleral melt with a partial thickness autologous scleral graft of the scleral melting. A 55-year-old male patient underwent pterygium resection surgery and intraoperative MMC application. The patient developed a deep melting area that almost reached the choroid...
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ژورنال
عنوان ژورنال: Journal of The Royal Society Interface
سال: 2019
ISSN: 1742-5689,1742-5662
DOI: 10.1098/rsif.2019.0427